Curry spice component may help slow prostate tumor growth

Friday, February 10, 2012

Curcumin, an active component of the Indian curry spice turmeric, may help slow down tumor growth in castration-resistant prostate cancer patients on androgen deprivation therapy (ADT), a study from researchers at Jefferson's Kimmel Cancer Center suggests.

Reporting in a recent issue of Cancer Research, Karen Knudsen, Ph.D., a Professor of Cancer Biology, Urology and Radiation Oncology at Thomas Jefferson University, and colleagues observed in a pre-clinical study that curcumin suppresses two known nuclear receptor activators, p300 and CPB (or CREB1-binding protein), which have been shown to work against ADT.

ADT aims to inhibit the androgen receptor?an important male hormone in the development and progression of prostate cancer?in patients. But a major mechanism of therapeutic failure and progression to advanced disease is inappropriate reactivation of this receptor. Sophisticated tumor cells, with the help of p300 and CPB, sometimes bypass the therapy.

Thus, development of novel targets that act in concert with the therapy would be of benefit to patients with castration-resistant prostate cancer.

For the study, prostate cancer cells were subjected to hormone deprivation in the presence and absence of curcumin with "physiologically attainable' doses. (Previous studies, which found similar results, included doses that were not realistic.)

Curcumin augments the results of ADT, and reduced cell number compared to ADT alone, the researchers found. Moreover, the spice was found to be a potent inhibitor of both cell cycle and survival in prostate cancer cells.

To help support their findings, the researchers also investigated curcumin in mice, which were castrated to mimic ADT. They were randomized into two cohorts: curcumin and control. Tumor growth and mass were significantly reduced in the mice with curcumin, the researchers report.

These data demonstrate for the first time that curcumin not only hampers the transition of ADT-sensitive disease to castration-resistance, but is also effective in blocking the growth of established castrate-resistant prostate tumors.

"This study sets the stage for further development of curcumin as a novel agent to target androgen receptor signaling," said Dr. Knudsen. "It also has implications beyond prostate cancer since p300 and CBP are important in other malignancies, like breast cancer. In tumors where these play an important function, curcumin may prove to be a promising therapeutic agent."

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Thomas Jefferson University: http://www.jeffersonhospital.org

Thanks to Thomas Jefferson University for this article.

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Source: http://www.labspaces.net/117538/Curry_spice_component_may_help_slow_prostate_tumor_growth

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Develop Into An Improved Version Of Yourself Following These Self ...

self development can be a smart move that can turn around the way you live for the better. You will wonder how to start making decisions to positively change your life. The basics of what you should know, and where to begin putting the pieces back together, are contained in this article.

You should try to become the best at what you do. If you are passionate enough, you can become truly great. Even though being the very best at what you do is out of the reach of most people, everyone can try to be an inspirational success in their particular field. Increase your professional skill set, and you will feel a lot better about yourself.

You should always strive to be the best in your area. The passions you have should always make you want to achieve greatness. Do not worry if you are not the best at what you do: the important part is to enjoy it and inspire others. By increasing your value within your field of study or work, you can enjoy benefits including higher self-esteem. One way to do this is through soft skills training.

Don?t be disorganized anywhere in your life. Organization will make you feel good about yourself, and make you feel confident. Disorganization is a big stress inducer, so organization will help with that, too. When you know where everything is, you probably feel calmer.

Perhaps you have set high goals for yourself and keep failing to attain them. If this is the case, it is a good idea to stop and think why. Do an Internet search for people pursuing the same goals. Note any differences between their strategies and yours. You could have impossible expectations of yourself or just not have a committed dedication to solving your problems.

Approach life with wisdom and modesty. There are lessons to be learned from everyday situations; learn to accept the things you have no control over in your life. Use modesty to work within your given limits. The wisdom you have learned from the past will help you make better decisions, with better outcomes, in the future!

Choose very specific personal development goals so that you have a clear path to success. Defining your goals and researching what you can do to get there is the key to success. This makes conquering your most challenging obstacles first, which means you succeed more quickly.

As you can probably see by now, personal development is not an easy process. That said, if you do some introspection and take advantage of social support, you should be able to accomplish this, and maybe even teach others. These suggestions should assist you on your journey.

Source: http://jaucoandassociates.com/4309/develop-into-an-improved-version-of-yourself-following-these-self-improvement-suggestions/

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Commercial Loan Workout Specialist Breakwater Equity Partners ...

San Diego, CA (PRWEB) March 28, 2011

Breakwater Equity Partners, a consulting firm specializing in commercial loan workouts, today announced the firm has surpassed $ 1 billion in total loan workout volume. The 21-person firm, located in San Diego, CA, has been doubling every ninety days to accommodate the growing demand for commercial loan modifications.

Breakwater Equity attributes its fast growth and success to the hands-on experience of its team, with over 180 workout assignments completed or in progress. Breakwater utilizes a diverse team of specialized experts in the fields of finance, bankruptcy, banking, real estate law, litigation management and negotiation. Its a bittersweet success story, said Phil Jemmett, CEO of Breakwater Equity Partners. While we are not excited about the state of the economy and the downturn in the real estate market, we are enthusiastic about the opportunity to help property owners and investors save their troubled properties and resolve their personal guarantees. All of our clients are dealing with a high level of financial and emotional pain, as the real estate collapse has destroyed years of hard work and created an uncertain future.

Breakwater has performed a wide variety of commercial loan workouts on the way to $ 1 billion, from single asset workouts on $ 1 Million loans, to multi-asset real estate portfolios exceeding $ 100 Million (minimum loan size is now $ 5 Million). The company has worked on just about every real estate asset class in a wide variety of locations across the U.S. including office buildings, industrial, retail, from strip centers to large shopping malls, multi-family residential, mixed use, master-planned communities, broken construction projects, residential and land development, golf courses, farming operations and manufacturing facilities.

We see no immediate end to the limited availability of credit, said Armand Nicholi, CFO of Breakwater Equity. The banking industry is not healthy right now. Every day we come across banks that are refusing to recognize the extent of their credit losses. Banks arent coming clean with regulators, investors, or the public. The bad loans are clogging up the financial system, and unless we face up to this problem we are going to be where Japan was back in the 1990s. After the last real estate melt down, the RTC liquidated all the bad debts; it was extremely painful, but it cleaned up lender balance sheets, restored the credit markets, and quickly allowed the economy to get back on its feet. We dont seem willing to go through that process this time around, so the pain will continue. The real estate market will not return to normal conditions until credit is available on commercially-reasonable terms.

Breakwater also has been working on TIC (tenant-in-common) loan workouts and is the consulting group managing the Met Center 10 office building workout in Austin, Texas, which has been at the center of controversy over Grubb & Elliss judgment of fraud and gross negligence in their dealings with and disclosures to TIC investment members as reported in the Wall Street Journal (Ruling Offers a Peek Into Boom?s Fallout ? Anton Troianovsky, December 22, 2010).

According to our research there are over $ 1.7 Trillion in commercial real estate loans that will be maturing by 2015, $ 1.1 Trillion of which will likely be under water, continued Phil Jemmett. We dont see the commercial real estate market improving significantly during the next few years. With sluggish job growth, increasing oil prices, a declining housing market, ballooning government debt, and tight credit, it seems unlikely that the commercial market will recover in the near term. As these underwater loans hit maturity, an orderly debt restructuring process is in the best interests of both borrowers and lenders. We believe commercial loan workouts are the most efficient way of resolving these issues, and an effective alternative to uncertain, costly, and lengthy bankruptcy and litigation processes.

About Breakwater Equity Partners

Breakwater Equity Partners is a privately-owned real estate consulting firm located in San Diego, CA, providing commercial loan workout strategies and negotiation services to property owners and investors throughout the U.S. The Breakwater team, consisting of experts in finance, banking, real estate and law, has worked on over 175 commercial loan workouts throughout the US, with deep experience in a wide variety of real estate classes, including office, industrial, retail, multi-family, mixed use, master-planned communities, residential and land development, golf courses, and farming operations. Breakwater also specializes in Tenant-in-Common loan workouts. For more information on Breakwater Equity Partners, please call 858-490-3630 or visit http://www.breakwaterequity.com. Read our commercial loan workout blog at http://www.breakwaterequity.com/blog.

Media Contact

Victoria Cunningham

victoria(at)breakwaterequity(dot)com

858-490-3630 x112

# # #

Source: http://chiefimplementor.com/2012/02/10/commercial-loan-workout-specialist-breakwater-equity-partners-passes-1-billion-in-loan-workout-volume/

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WEDDING PHOTOGRAPHER IN NJ

[unable to retrieve full-text content]WEDDING PHOTOGRAPHER IN NJ. ... A significant compound, the museums features an over 50 art galleries and science centers. The mini ... Pay a visit to view the Wars of America monument which is a work of the Mount Rushmore artist.

Source: http://www.articlerich.com/Article/WEDDING-PHOTOGRAPHER-IN-NJ/1955602

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Source: http://www.pc-pingan.com/english/?p=3692

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Episode 018 ? Building Gamer Community | Self-Critical Hits

Here?s the 2nd part of our talk with Rose Cowman ? founder of the recently completed, and by all accounts completely awesome Fabricated Realities story gaming con ? and the mysterious yet devastating Danielle, both visitors from the frozen south. This time we talk about building and/or finding community and safe space through gaming. We also make grand plans for an RPG about living in an anarcho-punk house (the dreaded and arcane chore wheel will figure prominently).

Hosts: Tori, Tanya, Ross, Danielle, James, Tobin, Caleb, David

Podcast: Play in new window | Download

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Source: http://www.selfcriticalhits.com/?p=133

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A Look At Pheromone Cologne And How It Can Help People Attract ...

Can you imagine an undetectable, invisible force that is just so powerful to an extent of overriding your sense of reason, drawing you to an individual with almost an animalistic passion. One word can be used to describe this; pheromones, a word emanating from two Greek terms pherein and hormone which mean ?excitement carrier?. Normally, animals secret pheromones that is odorless. This natural secretion from animals, meant to attract mates, is what is synthesized to make pheromone cologne, which are then marketed to consumers as a potion of to aid in elevating sexual attractiveness.

There has been scientific research for years to establish whether humans, as animals exude these scents, with a special focus on two small pits in a very minute organ, positioned some few centimeters above the nose. The findings were positive. The information below gives a comprehensive explanation on how pheromone cologne can be used to attract the opposite sex.

Scent emitted from this chemical are important in making the product useful for attraction. The smell produced by individuals in romance has always proved to have an incomparable impact. The memory of how the other party smelled during romantic times can stay for so long after that emotional occasion.

The manufacturers of these products always have this in mind, scent has the potential of evoking desires and arouses an individual sexually. For this reason, when one wears this product made from a combination meant to attract the opposite sex, the results will be positive.

Numerous researches also prove this fact. For instance, scent emanating from cheese pizza will increase the flow of blood to the penis by roughly five percent, buttered popcorn by nine percent, and pumpkin pie and lavender each by forty percent. A slight stimulation effect will also be witness in women when lavender and pumpkin are used. Interestingly, a combination of licorice with the smell of cucumber creates a remarkable blood flow to the woman?s vagina.

The use of the human pheromone also causes the attraction of the opposite sex. This is because these scents commonly found in an individual?s urine and sweat not only dictates the sexual behavior in humans but also attracts persons of the other sex.

An organ referred to as vemeronasal detects the chemical and attracts people of the opposite sex to the individual wearing the cologne. The desired effect, which is attraction of the opposite sex, has been achieved by use of this chemical substance in pheromone colognes.

You can find a detailed summary of the benefits and advantages of using pheromones and unbiased pheromone product reviews on our site, today.

Source: http://www.selfimprovementdirectory.info/self-improvement/a-look-at-pheromone-cologne-and-how-it-can-help-people-attract-the-opposite-sex-2/

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